| Samurai Shodown V |
| Samurai Warriors |
| Scaler |
| SCAR: Squadra Corse Alfa Romeo |
| Scarface: The World is Yours |
| Scooby-Doo! Night of 100 Frights |
| SeaBlade |
| Second Sight |
| Secret Weapons Over Normandy |
| Sega GT 2002 / Jet Set Radio Future Double Pack (4) |
| Sega GT Online |
| Sega Soccer Slam |
| Serious Sam (2) |
| Serious Sam II |
| Shadow the Hedgehog (4) |
| Shattered Union |
| Shellshock: Nam '67 |
| Shenmue II (2) |
| Shrek Super Party |
| Sid Meier's Pirates! Live The Life (2) |
| Silent Hill 2: Restless Dreams |
| Silent Hill 4: The Room (2) |
| Silent Scope Complete |
| Simpsons: Hit & Run, The (2) |
| Simpsons: Road Rage, The (3) |
| Sims 2, The |
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